59. L. Petrou, S. Ladame
Lab Chip, 2022, 22, 463-475.
On-chip miRNA extraction platforms: recent technological advances and implications for next generation point-of-care nucleic acid tests.
58. S. Cai, T. Pataillot-Meakin, A. Shibakawa, R. Ren, C. L. Bevan, S. Ladame, A.P. Ivanov, J.B. Edel
Nat. Comm., 2021, 12, 3515.
Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum.
57. D. Al Sulaiman, A. Gatehouse, A.P. Ivanov, J. B. Edel, S. Ladame
ACS Appl. Mater. Interfaces., 2021, 13, 26673-26681.
Length dependent, single-molecule analysis of short double-stranded DNA fragments through Hydrogel-Filled Nanopores: A potential tool for size-profiling cell-free DNA.
56. P. Gillespie, R.B. Channon, X. Meng, M.N. Islam, S. Ladame, D. O'Hare
Biosens. Bioelectron., 2021, 176, 112891
Nucleic acid sensing via electrochemical oligonucleotide-templated reactions
55. S. Pavagada, R.B. Channon, J.Y.H. Chang, S.H. Kim, D. MacIntyre, P.R. Bennett, V. Terzidou, S. Ladame
Chem. Commun., 2019, 55, 12451-12454
Oligonucleotide-Templated Lateral Flow Assays for Amplification-Free Sensing of Circulating microRNAs
54. D. Al Sulaiman J.Y.H. Chang, N.R. Bennett, H. Topouzi, C.A. Higgins, D.J. Irvine, S. Ladame
ACS Nano, 2019, 13, 8, 9620-9628
Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid
53. P. Gillespie, S. Ladame, D. O'Hare
Analyst, 2019, 144, 114-129
Molecular methods in electrochemical microRNA detection
52. S. Pavagada, S. Ladame
CHIMIA (Aarau), 2018, 72, 809-814
Platforms for biorthogonal oligonucleotide-templated reactions: Translating concepts into devices
51. D. Al Sulaiman, P. Cadinu, A.P. Ivanov, J.B. Edel, S. Ladame
Nano Lett., 2018, 18, 6084-6093
Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing
50. P. Cadinu, B.P. Nadappuram, D.J. Lee, J.Y.Y. Sze, G. Campolo, Y. Zhang, A. Shevchuk, S. Ladame, T. Albrech, Y. Korchev, A.P. Ivanov, J.B. Edel
Nano Lett., 2017, 17, 6376–6384
Single molecule trapping and sensing using dual nanopores separated by a zeptoliter nanobridge
49. D. Al Sulaiman, J.Y.H. Chang, S. Ladame
Angew. Chem. Int. Ed, 2017, 56, 5247-5251
Subnanomolar detection of oligonucleotides through templated fluorogenic reaction in hydrogels: controlling diffusion to improve sensitivity
48. M. Zuffo, S. Ladame, F. Doria, M. Freccero
Sens. Actuators B. Chem, 2017, 245, 780-788
Tuneable coumarin-NDI dyads as G-quadruplex specific light-up probes
47. D. Al Sulaiman, G.A.D. Metcalf, S. Ladame
Converg. Sci. Phys. Oncol., 2017, 3, 016001
Engineering innovative solutions to screen for prostate cancer
46. S. Panich, M.H. Sleiman, I. Steer, S. Ladame, J.B. Edel
ACS Sensors, 2016, 1, 1097-1102
Real-time monitoring of Ligand binding to G-Quadruplex and duplex DNA by whispering gallery mode (WGM) sensing
45. G.A. Metcalf, A. Shibakawa, H. Patel, A. Sita-Lumsden, A. Zivi, N. Rama, C.L. Bevan, S. Ladame
Anal. Chem., 2016, 88, 8091-8098
Amplification-free detection of circulating microRNA biomarkers from body fluids based on fluorogenic oligonucleotide-templated reaction between engineered peptide nucleic acid probes: Application to prostate cancer diagnosis
44. M. Zuffo, F. Doria, V. Spalluto, S. Ladame, M. Freccero
Chem. Eur. J., 2015, 21, 17596-17600
Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad
43. Y. Choi, G. Metcalf, M. Sleiman, D. Vair-Turnbull, S. Ladame
Bioorg. Med. Chem., 2014, 22, 4395-4398
Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications
42. M. Sleiman, S. Ladame
Chem. Commun., 2014, 50, 5288-5290
Synthesis of squaraine dyes under mild conditions: Applications for labelling and sensing of biomolecules
41. A. Fallah-Araghi, K. Meguellati, J.-C. Baret, A. El Harrak, T. Mangeat, M. Karplus, S. Ladame, C.M. Marques, A. Griffiths
Phys. Rev. Lett., 2014, 112, 28301
Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments
Editor’s suggestion; highlighted in Nature
40. K. Meguellati, A. Fallah-Araghi, J.-C. Baret, A. El Harrak, T. Mangeat, C. Marques, A. Griffiths, S. Ladame
Chem. Commun., 2013, 49, 11332-11334
Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms
39. M. Najah, E. Mayot, I.P. Wijaya, A. Griffiths, S. Ladame, A. Drevelle
Anal. Chem., 2013, 85, 9807-9814
New glycosidase substrates for droplet-based microfluidics screening
38. C. Percivalle, T. Mahmood, S. Ladame
MedChemComm., 2013, 4, 211-215
Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters
37. C. Percivalle, J.F. Bartolo, S. Ladame
Org. Biomol. Chem., 2013, 11, 16-26
Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process
36. T. Mahmood, Y. Wu, D. Loriot, M. Kuimova, S. Ladame
Chem. Eur. J., 2012, 18, 12349-12356
Closing the ring to bring up the light: Synthesis of a hexacyclic acridinium cyanine dye
35. K. Meguellati, S. Ladame
Top. Curr. Chem., 2012, 322, 291-314
Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity
34. K. Meguellati, S. Ladame, M. Spichty
Dyes & Pigments, 2011, 90, 114-118
A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes
33. G. Koripelly, K. Meguellati, S. Ladame
Bioconjugate Chem., 2010, 21, 2103-2109
Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes
32. K. Meguellati, M. Spichty, S. Ladame
Mol. BioSyst., 2010, 6, 1694-1699
Synthesis, Spectroscopic and DNA Alkylating Properties of Malondialdehyde (MDA) bis-Imine Fluorescent Adducts
31. K. Meguellati, G. Koripelly, S. Ladame
Angew. Chem. Int. Ed., 2010, 49, 2738-2742
DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic reaction for Sensing G-Quadruplex Formation
30. T. Mahmood, A. Paul, S. Ladame
J. Org. Chem., 2010, 75, 204-207
Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes
29. A. Paul, S. Ladame
Org. Letters, 2009, 11, 4894-4897
9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo
28. K. Meguellati, M. Spichty, S. Ladame
Org. Letters, 2009, 11, 1123-1126
Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes
27. J.E. Redman, J. M. Granadino-Roldán, J. A. Schouten, S. Ladame, A. P. Reszka, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2009, 7, 76-84
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
26. A. Paul, P. Sengupta, Y. Krishnan, S. Ladame
Chem. Eur. J., 2008, 14, 8682-8689
Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex
25. V.A. Soldatenkov, A.A. Vetcher, T. Duka, S. Ladame
ACS Chem. Biol., 2008, 3, 214-219
First Evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1
24. S. Ladame
Org. Biomol. Chem., 2008, 6, 219-226
Dynamic Combinatorial Chemistry: on the road to fulfilling the promise
23. P.S. Shirude, E.R. Gillies, S. Ladame, F. Godde, K. Shin-Ya, I. Huc, S. Balasubramanian
J. Am. Chem. Soc., 2007, 129, 11890-11891
Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
22. J. E. Redman, S. Ladame, A.P. Reszka, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2006, 4, 4364-4369
Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
21. K. Jantos, R. Rodriguez, S. Ladame, P. Shirude, S. Balasubramanian
J. Am. Chem. Soc., 2006, 128, 13662-13663
Oxazole-based Peptide Macrocycles : A new Class Of G-Quadruplex Binding Ligands
20. D.P.N. Gonçalves, S. Ladame, S. Balasubramanian, J.K.M. Sanders
Org. Biomol. Chem., 2006, 4, 3337-3342
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
19. J.J. Green, S. Ladame, L. Ying, D. Klenerman, S. Balasubramanian
J. Am. Chem. Soc., 2006, 128, 9809-9812
Investigating a Quadruplex-Ligand Interaction by Unfolding Kinetics
18. H. Fernando, A.P. Reszka, J. Huppert, S. Ladame, S. Rankin, A.R. Venkitaraman, S. Neidle, S. Balasubramanian
Biochemistry, 2006, 45, 7854-7860
A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
17. S. Ladame, J.A. Schouten, J. Roldan, J.E. Redman, S. Neidle, S. Balasubramanian
Biochemistry, 2006, 45, 1393-1399
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein
16. L. Azéma, R. Baron, S. Ladame
Current Enzyme Inhibition (review), 2006, 2, 61-72
Targeting enzymes with phosphonate-based inhibitors : mimics of tetrahedral transition states and stable isosteric analogues of phosphates
15. S. Ladame, A.M. Whitney, S. Balasubramanian
Angew. Chem. Int. Ed., 2005, 44, 5736-5739
Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
Highlighted in Nature Chem. Biol., 2005, 1(5), 251
14. L. Azéma, S. Ladame, C. Lapeyre, A. Zwick, F. Lakhdar-Ghazal
Spectrochim. Acta A, 2005, 62, 287-292
Does phosphoryl protonation occurs in aqueous phosphoesters solutions
13. S. Rankin, A.P. Reszka, J. Huppert, M. Zloh, G.N. Parkinson, A.K. Todd, S. Ladame, S. Balasubramanian, S. Neidle
J. Am. Chem. Soc., 2005, 127 (30), 10584-10589
Putative DNA quadruplex formation within the human c-kit oncogene
12. S. Ladame, R. Fauré, C. Denier, F. Lakhdar-Ghazal, M. Willson
Org. Biomol. Chem., 2005, 3, 2070-2072
Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues
11. S. Ladame, J.A. Schouten, J. Stuart, J. Roldan, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2004, 2, 2925-2932
Tetrapeptides induce specific recognition for G-quadruplexes when conjugated to a DNA-binding platform
10. S.D. Patel, M. Isalan, G. Gavory, S. Ladame, Y. Choo, S. Balasubramanian
Biochemistry, 2004, 43, 13452-13458
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
9. A.M. Whitney, S. Ladame, S. Balasubramanian
Angew. Chem. Int. Ed., 2004, 43, 1143-1146
Templated Ligand Assembly by Using G-Quadruplex DNA and Dynamic Covalent Chemistry
8. S. Ladame, M.S. Castilho, C.H.T.P. Silva, C. Denier, V. Hannaert, J. Périé, G. Oliva, M. Willson
Eur. J. Biochem., 2003, 270, 4574-4586
Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid. Selective inhibition by structure-based design
7. M. S. Castilho, F. Pavao, G. Oliva, S. Ladame, M. Willson, J. Périé
Biochemistry, 2003, 42 (23), 7143-7151
Evidence for the Two Phosphate Binding Sites of an Analogue of the Thioacyl Intermediate for the Trypanozoma cruzi Glyceraldehyde-3-phosphate-Dehydrogenase Catalyzed-Reaction from its Crystal Structure
6. J. A. Schouten, S. Ladame, S. J. Mason, M. A. Cooper, S. Balasubramanian
J. Am. Chem. Soc., 2003, 125 (19), 5594-5595
Peptide-Hemicyanine based G-quadruplex ligands by partial combinatorial selection
5. S. Ladame, R. J. Harrison, S. Neidle, S. Balasubramanian
Org. Letters, 2002, 4 (15), 2509-2512
Solid-Phase Synthesis of Symmetrical 3,6-Bispeptide-Acridone Conjugates
4. S. Ladame, M. Willson, J. Périé
Eur. J. Org. chem., 2002, 15, 2640-2648
A Convenient Synthesis of Dibenzyl a,a-Difluoromethyl-b-ketophosphonates
3. S. Ladame, M. Bardet, J. Périé, M. Willson
Bioorg. Med. Chem., 2001, 9, 773-783
Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues
2. S. Ladame, S. Claustre, M. Willson
Phosphorus, Sulfur, and Silicon, 2001, 174, 37-47
Selective phosphorylation on primary alcohols of unprotected polyols
1. L. Nzita, S. Ladame, L. Gomez, S. Moreau
Nucleosides & Nucleotides, 1997, 16, 1781-1784
Synthesis of a 2-hydroxy-oxolane derivative as a new potential crosslinking agent of DNA
Lab Chip, 2022, 22, 463-475.
On-chip miRNA extraction platforms: recent technological advances and implications for next generation point-of-care nucleic acid tests.
58. S. Cai, T. Pataillot-Meakin, A. Shibakawa, R. Ren, C. L. Bevan, S. Ladame, A.P. Ivanov, J.B. Edel
Nat. Comm., 2021, 12, 3515.
Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum.
57. D. Al Sulaiman, A. Gatehouse, A.P. Ivanov, J. B. Edel, S. Ladame
ACS Appl. Mater. Interfaces., 2021, 13, 26673-26681.
Length dependent, single-molecule analysis of short double-stranded DNA fragments through Hydrogel-Filled Nanopores: A potential tool for size-profiling cell-free DNA.
56. P. Gillespie, R.B. Channon, X. Meng, M.N. Islam, S. Ladame, D. O'Hare
Biosens. Bioelectron., 2021, 176, 112891
Nucleic acid sensing via electrochemical oligonucleotide-templated reactions
55. S. Pavagada, R.B. Channon, J.Y.H. Chang, S.H. Kim, D. MacIntyre, P.R. Bennett, V. Terzidou, S. Ladame
Chem. Commun., 2019, 55, 12451-12454
Oligonucleotide-Templated Lateral Flow Assays for Amplification-Free Sensing of Circulating microRNAs
54. D. Al Sulaiman J.Y.H. Chang, N.R. Bennett, H. Topouzi, C.A. Higgins, D.J. Irvine, S. Ladame
ACS Nano, 2019, 13, 8, 9620-9628
Hydrogel-Coated Microneedle Arrays for Minimally Invasive Sampling and Sensing of Specific Circulating Nucleic Acids from Skin Interstitial Fluid
53. P. Gillespie, S. Ladame, D. O'Hare
Analyst, 2019, 144, 114-129
Molecular methods in electrochemical microRNA detection
52. S. Pavagada, S. Ladame
CHIMIA (Aarau), 2018, 72, 809-814
Platforms for biorthogonal oligonucleotide-templated reactions: Translating concepts into devices
51. D. Al Sulaiman, P. Cadinu, A.P. Ivanov, J.B. Edel, S. Ladame
Nano Lett., 2018, 18, 6084-6093
Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing
50. P. Cadinu, B.P. Nadappuram, D.J. Lee, J.Y.Y. Sze, G. Campolo, Y. Zhang, A. Shevchuk, S. Ladame, T. Albrech, Y. Korchev, A.P. Ivanov, J.B. Edel
Nano Lett., 2017, 17, 6376–6384
Single molecule trapping and sensing using dual nanopores separated by a zeptoliter nanobridge
49. D. Al Sulaiman, J.Y.H. Chang, S. Ladame
Angew. Chem. Int. Ed, 2017, 56, 5247-5251
Subnanomolar detection of oligonucleotides through templated fluorogenic reaction in hydrogels: controlling diffusion to improve sensitivity
48. M. Zuffo, S. Ladame, F. Doria, M. Freccero
Sens. Actuators B. Chem, 2017, 245, 780-788
Tuneable coumarin-NDI dyads as G-quadruplex specific light-up probes
47. D. Al Sulaiman, G.A.D. Metcalf, S. Ladame
Converg. Sci. Phys. Oncol., 2017, 3, 016001
Engineering innovative solutions to screen for prostate cancer
46. S. Panich, M.H. Sleiman, I. Steer, S. Ladame, J.B. Edel
ACS Sensors, 2016, 1, 1097-1102
Real-time monitoring of Ligand binding to G-Quadruplex and duplex DNA by whispering gallery mode (WGM) sensing
45. G.A. Metcalf, A. Shibakawa, H. Patel, A. Sita-Lumsden, A. Zivi, N. Rama, C.L. Bevan, S. Ladame
Anal. Chem., 2016, 88, 8091-8098
Amplification-free detection of circulating microRNA biomarkers from body fluids based on fluorogenic oligonucleotide-templated reaction between engineered peptide nucleic acid probes: Application to prostate cancer diagnosis
44. M. Zuffo, F. Doria, V. Spalluto, S. Ladame, M. Freccero
Chem. Eur. J., 2015, 21, 17596-17600
Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad
43. Y. Choi, G. Metcalf, M. Sleiman, D. Vair-Turnbull, S. Ladame
Bioorg. Med. Chem., 2014, 22, 4395-4398
Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: Concept and biomedical applications
42. M. Sleiman, S. Ladame
Chem. Commun., 2014, 50, 5288-5290
Synthesis of squaraine dyes under mild conditions: Applications for labelling and sensing of biomolecules
41. A. Fallah-Araghi, K. Meguellati, J.-C. Baret, A. El Harrak, T. Mangeat, M. Karplus, S. Ladame, C.M. Marques, A. Griffiths
Phys. Rev. Lett., 2014, 112, 28301
Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments
Editor’s suggestion; highlighted in Nature
40. K. Meguellati, A. Fallah-Araghi, J.-C. Baret, A. El Harrak, T. Mangeat, C. Marques, A. Griffiths, S. Ladame
Chem. Commun., 2013, 49, 11332-11334
Enhanced imine synthesis in water: from surfactant-mediated catalysis to host-guest mechanisms
39. M. Najah, E. Mayot, I.P. Wijaya, A. Griffiths, S. Ladame, A. Drevelle
Anal. Chem., 2013, 85, 9807-9814
New glycosidase substrates for droplet-based microfluidics screening
38. C. Percivalle, T. Mahmood, S. Ladame
MedChemComm., 2013, 4, 211-215
Two-in-one: a pH-sensitive, acridine-based, fluorescent probe binds G-quadruplexes in oncogene promoters
37. C. Percivalle, J.F. Bartolo, S. Ladame
Org. Biomol. Chem., 2013, 11, 16-26
Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process
36. T. Mahmood, Y. Wu, D. Loriot, M. Kuimova, S. Ladame
Chem. Eur. J., 2012, 18, 12349-12356
Closing the ring to bring up the light: Synthesis of a hexacyclic acridinium cyanine dye
35. K. Meguellati, S. Ladame
Top. Curr. Chem., 2012, 322, 291-314
Reversible Covalent Chemistries Compatible with the Principles of Constitutional Dynamic Chemistry: New Reactions to Create More Diversity
34. K. Meguellati, S. Ladame, M. Spichty
Dyes & Pigments, 2011, 90, 114-118
A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes
33. G. Koripelly, K. Meguellati, S. Ladame
Bioconjugate Chem., 2010, 21, 2103-2109
Dual Sensing of Hairpin and Quadruplex DNA Structures Using Multicolored Peptide Nucleic Acid Fluorescent Probes
32. K. Meguellati, M. Spichty, S. Ladame
Mol. BioSyst., 2010, 6, 1694-1699
Synthesis, Spectroscopic and DNA Alkylating Properties of Malondialdehyde (MDA) bis-Imine Fluorescent Adducts
31. K. Meguellati, G. Koripelly, S. Ladame
Angew. Chem. Int. Ed., 2010, 49, 2738-2742
DNA-Templated Synthesis of Trimethine Cyanine Dyes: A Versatile Fluorogenic reaction for Sensing G-Quadruplex Formation
30. T. Mahmood, A. Paul, S. Ladame
J. Org. Chem., 2010, 75, 204-207
Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes
29. A. Paul, S. Ladame
Org. Letters, 2009, 11, 4894-4897
9-Amino Acridines Undergo Reversible Amine Exchange Reactions in Water: Implications on Their Mechanism of Action in Vivo
28. K. Meguellati, M. Spichty, S. Ladame
Org. Letters, 2009, 11, 1123-1126
Reversible Synthesis and Characterization of Dynamic Imino Analogues of Trimethine and Pentamethine Cyanine Dyes
27. J.E. Redman, J. M. Granadino-Roldán, J. A. Schouten, S. Ladame, A. P. Reszka, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2009, 7, 76-84
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
26. A. Paul, P. Sengupta, Y. Krishnan, S. Ladame
Chem. Eur. J., 2008, 14, 8682-8689
Combining G-Quadruplex Targeting Motifs on a Single Peptide Nucleic Acid Scaffold: A Hybrid (3+1) PNA-DNA Bimolecular Quadruplex
25. V.A. Soldatenkov, A.A. Vetcher, T. Duka, S. Ladame
ACS Chem. Biol., 2008, 3, 214-219
First Evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1
24. S. Ladame
Org. Biomol. Chem., 2008, 6, 219-226
Dynamic Combinatorial Chemistry: on the road to fulfilling the promise
23. P.S. Shirude, E.R. Gillies, S. Ladame, F. Godde, K. Shin-Ya, I. Huc, S. Balasubramanian
J. Am. Chem. Soc., 2007, 129, 11890-11891
Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands
22. J. E. Redman, S. Ladame, A.P. Reszka, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2006, 4, 4364-4369
Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
21. K. Jantos, R. Rodriguez, S. Ladame, P. Shirude, S. Balasubramanian
J. Am. Chem. Soc., 2006, 128, 13662-13663
Oxazole-based Peptide Macrocycles : A new Class Of G-Quadruplex Binding Ligands
20. D.P.N. Gonçalves, S. Ladame, S. Balasubramanian, J.K.M. Sanders
Org. Biomol. Chem., 2006, 4, 3337-3342
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
19. J.J. Green, S. Ladame, L. Ying, D. Klenerman, S. Balasubramanian
J. Am. Chem. Soc., 2006, 128, 9809-9812
Investigating a Quadruplex-Ligand Interaction by Unfolding Kinetics
18. H. Fernando, A.P. Reszka, J. Huppert, S. Ladame, S. Rankin, A.R. Venkitaraman, S. Neidle, S. Balasubramanian
Biochemistry, 2006, 45, 7854-7860
A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
17. S. Ladame, J.A. Schouten, J. Roldan, J.E. Redman, S. Neidle, S. Balasubramanian
Biochemistry, 2006, 45, 1393-1399
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein
16. L. Azéma, R. Baron, S. Ladame
Current Enzyme Inhibition (review), 2006, 2, 61-72
Targeting enzymes with phosphonate-based inhibitors : mimics of tetrahedral transition states and stable isosteric analogues of phosphates
15. S. Ladame, A.M. Whitney, S. Balasubramanian
Angew. Chem. Int. Ed., 2005, 44, 5736-5739
Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
Highlighted in Nature Chem. Biol., 2005, 1(5), 251
14. L. Azéma, S. Ladame, C. Lapeyre, A. Zwick, F. Lakhdar-Ghazal
Spectrochim. Acta A, 2005, 62, 287-292
Does phosphoryl protonation occurs in aqueous phosphoesters solutions
13. S. Rankin, A.P. Reszka, J. Huppert, M. Zloh, G.N. Parkinson, A.K. Todd, S. Ladame, S. Balasubramanian, S. Neidle
J. Am. Chem. Soc., 2005, 127 (30), 10584-10589
Putative DNA quadruplex formation within the human c-kit oncogene
12. S. Ladame, R. Fauré, C. Denier, F. Lakhdar-Ghazal, M. Willson
Org. Biomol. Chem., 2005, 3, 2070-2072
Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues
11. S. Ladame, J.A. Schouten, J. Stuart, J. Roldan, S. Neidle, S. Balasubramanian
Org. Biomol. Chem., 2004, 2, 2925-2932
Tetrapeptides induce specific recognition for G-quadruplexes when conjugated to a DNA-binding platform
10. S.D. Patel, M. Isalan, G. Gavory, S. Ladame, Y. Choo, S. Balasubramanian
Biochemistry, 2004, 43, 13452-13458
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
9. A.M. Whitney, S. Ladame, S. Balasubramanian
Angew. Chem. Int. Ed., 2004, 43, 1143-1146
Templated Ligand Assembly by Using G-Quadruplex DNA and Dynamic Covalent Chemistry
8. S. Ladame, M.S. Castilho, C.H.T.P. Silva, C. Denier, V. Hannaert, J. Périé, G. Oliva, M. Willson
Eur. J. Biochem., 2003, 270, 4574-4586
Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid. Selective inhibition by structure-based design
7. M. S. Castilho, F. Pavao, G. Oliva, S. Ladame, M. Willson, J. Périé
Biochemistry, 2003, 42 (23), 7143-7151
Evidence for the Two Phosphate Binding Sites of an Analogue of the Thioacyl Intermediate for the Trypanozoma cruzi Glyceraldehyde-3-phosphate-Dehydrogenase Catalyzed-Reaction from its Crystal Structure
6. J. A. Schouten, S. Ladame, S. J. Mason, M. A. Cooper, S. Balasubramanian
J. Am. Chem. Soc., 2003, 125 (19), 5594-5595
Peptide-Hemicyanine based G-quadruplex ligands by partial combinatorial selection
5. S. Ladame, R. J. Harrison, S. Neidle, S. Balasubramanian
Org. Letters, 2002, 4 (15), 2509-2512
Solid-Phase Synthesis of Symmetrical 3,6-Bispeptide-Acridone Conjugates
4. S. Ladame, M. Willson, J. Périé
Eur. J. Org. chem., 2002, 15, 2640-2648
A Convenient Synthesis of Dibenzyl a,a-Difluoromethyl-b-ketophosphonates
3. S. Ladame, M. Bardet, J. Périé, M. Willson
Bioorg. Med. Chem., 2001, 9, 773-783
Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues
2. S. Ladame, S. Claustre, M. Willson
Phosphorus, Sulfur, and Silicon, 2001, 174, 37-47
Selective phosphorylation on primary alcohols of unprotected polyols
1. L. Nzita, S. Ladame, L. Gomez, S. Moreau
Nucleosides & Nucleotides, 1997, 16, 1781-1784
Synthesis of a 2-hydroxy-oxolane derivative as a new potential crosslinking agent of DNA
PATENTS
2. Najah, M.; Drevelle, A.; Ladame, S.
Patent PCT/FR11/000504
Coumarines sulfonatees, leur synthèse, substrats fluorogeniques résultant d'un greffage de ces coumarines sur des sucres, le procédé d'obtention de ces substrats ainsi que leurs applications
1. Balasubramanian, S.; Jantos, K.; Ladame, S.
Patent PCT 2008/009942
Heteroaromatic-based peptide macrocycles as G-quadruplex ligands
PATENTS
2. Najah, M.; Drevelle, A.; Ladame, S.
Patent PCT/FR11/000504
Coumarines sulfonatees, leur synthèse, substrats fluorogeniques résultant d'un greffage de ces coumarines sur des sucres, le procédé d'obtention de ces substrats ainsi que leurs applications
1. Balasubramanian, S.; Jantos, K.; Ladame, S.
Patent PCT 2008/009942
Heteroaromatic-based peptide macrocycles as G-quadruplex ligands
BOOKS AND BOOK CHAPTERS
2. Sylvain Ladame, Jason Chang
Bioengineering Innovative Solution for Cancer
Elsevier academic press, 2019, ISBN: 9780128138861
1. M.H. Sleiman, S. Ladame
Future Medicine ebook, 2015, ISBN: 978-1-910419-68-7, chapter in Biological Relevance & Therapeutic Applications of DNA- & RNA-Quadruplexes
DNA G-quadruplexes under the spotlight
BOOKS AND BOOK CHAPTERS
2. Sylvain Ladame, Jason Chang
Bioengineering Innovative Solution for Cancer
Elsevier academic press, 2019, ISBN: 9780128138861
1. M.H. Sleiman, S. Ladame
Future Medicine ebook, 2015, ISBN: 978-1-910419-68-7, chapter in Biological Relevance & Therapeutic Applications of DNA- & RNA-Quadruplexes
DNA G-quadruplexes under the spotlight